Red Wine Grapes - a major source of anti-oxidant polyphenols

 

General Health and Longevity

In one of the earliest studies conducted on the longevity effects of trans-resveratrol, the life span of yeast cells was increased in a similar fashion to the proven calorie restriction method¹. Recent studies by Dr. David Sinclair have demonstrated the calorie restriction mimicking effects of trans-resveratrol intake on mice². The results showed that trans-resveratrol delays age related deterioration. Elderly mice fed trans-resveratrol showed signs of reversal of age-related conditions including cataracts, bone density decreases, decrease inflammation, cardiovascular conditions and motor coordination. In perhaps the most famous study conducted by Sinclair et al trans-resveratrol was found to alter the physiology of middle-aged mice fed a high calorie diet to that of mice on a standard diet and to significantly enhance their life span³. The observed changes related to increased insulin sensitivity, an increase in the number of chemical messengers blocking hunger and importantly increased mitochondrial number resulting in improved energy efficiency and motor function. These aspects are thought to be responsible for the observed effects of trans-resveratrol. The authors concluded that this data showed an overall improvement in the general health of the subjects and may be the foundation for new treatments for obesity-related disorders and diseases of aging.

A 2005 study by Juan et al showed that trans-resveratrol fed mice displayed significantly increased sperm counts than the control group⁴. An increase in the levels of testosterone and gonadotrophins was also observed in the trans-resveratrol group.