Evidence-Based Complementary and Alternative Medicine Volume 2013 (2013),

Article ID 851267, 11 pages

http://dx.doi.org/10.1155/2013/851267

Research Article Antihyperglycemic Effects of Short Term Resveratrol Supplementation in Type 2 Diabetic Patients

Conclusion and Summary

The results of this study clearly demonstrate that resveratrol supplementation in the presence of standard antidiabetic medication has major benefits in T2DM patients, which include a pronounced lowering of blood glucose, HbA1c, insulin levels, and insulin resistance, as well as improvement in HDL levels (Figure 2). Unlike earlier reports [21–23] which showed mild effects on hyperglycemia and hyperinsulinemia, our study highlights the marked changes and the potential of resveratrol as an antidiabetic molecule. It is also important to note the beneficial effects of resveratrol observed on metabolic parameters, despite the fact that there was no appreciable effect on body weight or body composition. Some of the observed reductions in HbA1c and HDL with resveratrol supplementation are very significant that they can be compared to benefits achieved with front line antidiabetic drugs. Other important observations which stem from this study are that: (a) 1 g/day of resveratrol supplementation for 45 days had no adverse effects in type 2 diabetic patients and (b) resveratrol not only complemented standard antidiabetic medication but also provided added protection (over standard antidiabetic therapy).

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